產(chǎn)品英文名稱：TGF-β1,human
產(chǎn)品中文名稱：人TGF-β1蛋白

TGF-β1產(chǎn)品介紹：
TGF-β1是一組蛋白超家族。TGF-β1是由兩個結(jié)構(gòu)相同或相似，分子量為12.5kD的亞單位通過二硫鍵連接而成的雙體。在人的心肌成纖維細胞、血管內(nèi)皮細胞和巨噬細胞等均有表達。TGF-β1信號通路的關(guān)鍵傳導分子為胞質(zhì)蛋白Smads,他們可以將TGF-β1信號直接由細胞膜受體傳導人細胞核內(nèi)，是受體激酶介導的細胞內(nèi)信號傳導的新途徑，為細胞信號跨膜后與核內(nèi)基因轉(zhuǎn)錄之間開通了一條簡便路徑。不同的Smad介導不同的TGF-β1家族成員的信號轉(zhuǎn)導。TGF-β1／Smad信號轉(zhuǎn)導通路活化后，可以促進相關(guān)基因的轉(zhuǎn)錄，如膠原蛋白的表達增高，也可通過調(diào)節(jié)MMPs／TIMPs表達的平衡抑制膠原降解，促進組織纖維化。

TGF-β1產(chǎn)品特性：
» TGF-β1活性經(jīng)過人源細胞鑒定，純度高。
» 生物活性在人源293細胞經(jīng)過SMAD實驗鑒定The EC50為 0.1–1.0 ng/ml。
» TGF-β1產(chǎn)品經(jīng)過SDS-PAGE 和HPLC雙層鑒定純度大于95%。

TGF-β1產(chǎn)品英文簡述：
Members of TGF-family are multifunctional cytokines that regulate cell proliferation, growth, differentiation and migration as well as synthesis of the extracellular matrix. The three human isoforms, TGF- 1,  2,  3, signal through the same receptor and elicit similar biological responses. The release of biologically active TGF-isoform from a latent complex involves proteolytic processing of the complex. TGF-1 is the most abundant isoform secreted by almost all cell types. Human TGF-1 is a 25.0kDa protein with each subunit containing 112 amino acid residues, linked by a disulfide bond.

• Purity: Greater than 95% as determined by SDS-PAGE and HPLC analyses
• Biological Activity: The activity was determined by using a SMAD reporter gene assay in human 293 cells. The EC50 ranges from 0.1 – 1.0 ng/ml.
• For Research Use Only. Not for Use in Humans.