產品英文名稱：R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A
產品中文名稱：R&D 338-AC-050重組人/小鼠/大鼠激活素A

R&D 338-AC-010 Recombinant Human/Mouse/Rat Activin A 產品研究背景
Activin and Inhibin are members of the TGFβ superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfidelinked dimers of the bioactive proteins .Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100% amino acid sequence identity with bovine, feline, mouse,porcine, and rat βA. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK4. Signaling through this receptor complex leads to Smad activation and regulation of activinresponsive gene transcription. The bioactivity of R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is regulated by a variety of mechanisms. BAMBI, Betaglycan, and Cripto are cellassociated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly .The intracellular formation of R&D 338-AC-010 Recombinant Human/Mouse/Rat Activin A can be prevented by the incorporation of the βA subunit into Activin AC or Inhibin A. And the bioavailability of R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is restricted by its incorporation into inactive complexes with α2Macroglobulin,Follistatin, and FLRG .

R&D 338-AC-050重組人/小鼠/大鼠激活素A產品簡介
激活素和抑制素是細胞因子TGF-β超家族的成員，參與廣泛的生物學過程，包括組織形態(tài)發(fā)生和修復，纖維化，炎癥，神經系統的發(fā)育，造血，生殖系統的功能，和癌變。R&D 338-AC-050 重組人/小鼠/大鼠激活素A是一種廣泛表達的同源二聚體的兩個βA鏈。 βA亞基也可以在異源與βB或βC亞基形成AB激活素和激活素AC 。R&D 338-AC-050 重組人/小鼠/大鼠激活素A的生物活性受多種機制調節(jié) 。 激活素細胞內形成A被βA亞基激活素AC或抑制素A 阻礙 。
激活素最初從性腺流體純化蛋白質，刺激垂體促卵泡刺激素（FSH）釋放的二硫鍵連接的二聚體蛋白。激活素蛋白具有廣泛的生物活性，包括中胚層誘導，神經細胞的分化，骨重塑，造血和生殖生理學的角色。激活素的異構體和轉化生長因子- β超家族的其他成員的結合的異源復合物的類型I和II型的絲氨酸 - 蘇氨酸激酶受體，這兩者都是必不可少的信號轉導中發(fā)揮其生物效應。

激活素的各種β亞基異構體的同二聚體或異二聚體，而抑制素是一個獨特的α亞基和的各種β亞基之一的異源二聚體。五β亞基（哺乳動物beta A, beta B, beta C, beta E and Xenopus beta D)至今已被克隆。激活素/抑制素的命名反映的蛋白質亞基組成：激活素A (beta A - beta A) ，激活素B(beta B - beta B)， AB激活素(beta A - beta B) ，抑制素(alpha - beta A)及抑制素B(alpha - beta B) 。

R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A 保存方法
Use a manual defrost freezer and avoid repeated freezethawcycles.
»12 months from date of receipt, -20to -70°C as supplied.
»1 month, 2 to 8 °C under sterile conditions after reconstitution.
»3 months, -20to -70°C under sterile conditions after reconstitution.

R&D 338-AC-050重組人/小鼠/大鼠激活素A系列產品訂購信息
R&D  Recombinant Human/Mouse/Rat Activin A  338-AC-01M  1 mg              
R&D  Recombinant Human/Mouse/Rat Activin A  338-AC-010  10 µg       
R&D  Recombinant Human/Mouse/Rat Activin A  338-AC-050  50 µg
For Research Use Only. Not for Use in Humans.